The Lakers held only a two-point halftime lead, but outscored the Timberwolves in the third quarter by 16.
Los Angeles won its 11th straight game and improved the best record in the NBA to 18-3.
Every other team in the Western Conference has lost at least seven games.
Pau Gasol contributed 17 points and Ron Artest had 16 for the Lakers, who made 8-of-25 shots from 3-point range.
Minnesota, which has lost three in a row and has won only three games this season, was led by Al Jefferson with 24 points.
Copyright 2009 by United Press International.
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