McNabb, who had been out with a rib injury, hit rookie Jeremy Maclin on TD passes of 51 and 40 yards and Leonard Weaver on a 20-yarder, ending up with 16 completions for 264 yards.
Brian Westbrook ran 7 yards for a touchdown for the Eagles (3-1).
Rookie Josh Johnson was 26-of-50 for 240 yards and two touchdowns for the Buccaneers (0-5).
Johnson threw two 9-yard TD passes to Kellen Winslow, who had nine receptions for 102 yards.
Philadelphia's win was the 100th in the NFL for Coach Andy Reid.
Copyright 2009 by United Press International.
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