Manning, who had been listed as questionable before the game with a heel injury, threw a 30-yard TD pass to Mario Manningham and a 9-yarder to Hakeem Nicks in the second quarter, before being replaced by David Carr.
Bradshaw's two scoring runs, both in the first quarter, were from 1 and 19 yards.
Carr passed for 90 yards and scored on a 12-yard run.
The Giants (5-0) out-gained Oakland 483-124.
Michael Bush scored on a 5-yard run for the Raiders (1-4).
Copyright 2009 by United Press International.
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