Matsui's only hit erased a 4-3 deficit with one out in the final inning, handing Philadelphia closer Brad Lidge (0-7) his10th blown save this season.
Hunter Pence drove in three runs with a two-run, second-inning homer and an RBI single in the third.
Chris Coste and Miguel Tejada also each had one hit for the Astros, who made the most of four hits, giving them three wins in their last five games.
Closer Jose Valverde (3-2) pitched a 1-2-3 ninth for the win.
Pedro Feliz had two hits and one RBI for the Phillies, who have lost three of four.
Copyright 2009 by United Press International.
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