Marquis (12-6) worked eight innings, allowing a run and five hits. He also drove in two runs with a double.
Brad Hawpe and Ian Stewart each belted a solo home run for Colorado, which has won eight of its last 11 contests.
Kevin Kouzmanoff produced a sacrifice fly to score a run in San Diego's 13th loss in 16 games this month.
Loser Mat Latos (0-1) yielded two runs and three hits over four innings in his major league debut.
Copyright 2009 by United Press International.
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