Carlos Beltran hit a two-run homer, and David Wright and Ryan Church each had solo homers for New York. Jimmy Rollins, who was 3-for-4, had a two-run homer, and Ryan Howard, Raul Ibanez and Chase Utley had solo homers for Philadelphia.
Santana (8-3) gave up a season-high five earned runs on eight hits. He also had a run-scoring double. Francisco Rodriguez worked the ninth to earn his 16th save in as many chances.
Clay Condrey (4-1) took the loss after giving up the go-ahead run in the sixth.
Philadelphia starter J.A. Happ, allowed four runs on six hits and four walks in 5 1/3 innings.
Copyright 2009 by United Press International.
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