Youkilis and Lowell scored two runs apiece in the interleague game.
Nick Green added two RBI for the Red Sox.
Winner Tim Wakefield (6-2) worked six innings, allowing five runs and seven hits.
Ramon Castro homered and Jeremy Reed, Carlos Beltran, Gary Sheffield and David Wright each drove in a run for the Mets, who have lost five of their last seven games.
Tim Redding (0-1) was the loser. Redding allowed six runs and eight hits in 4 2/3 innings.
Copyright 2009 by United Press International.
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