The Reds scored five runs in the fifth inning. Brandon Phillips drove in two runs and scored once and Joey Votto had three hits and scored three runs for the Reds.
Johnny Cueto (10-10) gave up two runs on nine hits in five innings for the win.
Zach Duke (10-15) took the loss after allowing five runs on nine hits in six innings.
Andrew McCutchen went 2-for-4 with a solo homer and two RBI, Ronny Cedeno, and Robinzon Diaz each had an RBI, and Lastings Milledge went 3-for-5 with two runs scored for Pittsburgh.
Copyright 2009 by United Press International.