Hawkins was in his fifth season at Colorado and the Buffaloes were 19-39 with him as coach. Colorado fell to 3-6 this season after Kansas mounted a school-record comeback in defeating the Buffaloes 52-45 last Saturday.
Colorado has lost its last five games after a 3-1 start.
"However, things have gone downhill (from the 3-1 start)," said Colorado Athletic Director Mike Bohn. "While we recognize the progress that we have made in several areas during nearly five years under Dan, the negativity and divisiveness that is associated with the current leadership has become detrimental and is beyond repair to our current enterprise and it's time to make a change."
Bohn said Buffaloes assistant coach Brian Cabral would take over the team on an interim basis. Colorado has three games remaining this season, its final in the Big 12 Conference before moving to the Pac-12, against Iowa State and Kansas State at home and at Nebraska.
Prior to arriving in Boulder, Hawkins was 53-11 in five years at Boise State. His teams were 37-3 in Western Athletic Conference play, which included four straight conference titles -- three outright -- from 2002-05.
Cabral is in his 22nd season at Colorado and 21st year as a full-time staff member.
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