Ewing's sarcoma molecule identified

Washington -- U.S. scientists have found a small molecule they say can block the action of the oncogene that causes Ewing's sarcoma, a rare cancer.

The Georgetown University researchers said if further studies replicate their finding it could lead to the first targeted therapy to treat the disease, which can produce tumors anywhere in the body.

The scientists said their research suggests the unique way in which the molecule works -- through a so-called protein-protein interaction -- could provide a model upon which to design other therapies.

"I think this holds really wonderful promise as a unique way of targeting fusion proteins," said Dr. Jeffrey Toretsky, who led the study. "People thought it wasn't possible to have a small molecule that can bind between flexible proteins, but we have shown that it can be done."

The study was conducted in laboratory cells, so additional research is necessary before the novel agent can be tested in patients, Toretsky said.

The findings were presented Sunday in San Diego during the annual meeting of the American Association for Cancer Research.

Copyright 2008 by United Press International.