AFC South-leading Jacksonville (8-5) got 159 yards passing on 11-of-22 attempts from David Garrard, who winged three TD passes with one interception on the day.
Jones-Drew ended up with 101 yards on 23 carries and Rashad Jennings added 109 rushing yards and a 74-yard score for the Jaguars, who won for the fifth time in six games.
Jason Campbell tossed for 324 yards and two touchdowns for the Raiders (6-7), who who lost for the third time in four games.
Darren McFadden gained 123 yards and added two scores on 16 carries in the setback.
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