Wayns' bucket and free throw put Villanova up 81-79. Corey Fisher made three foul shots down the stretch and Sam Mills couldn't connect on a potential game-tying 3-pointer for La Salle as time expired.
Wayns finished with 19 points and Fisher and Corey Stokes each added 16 for Villanova (8-1).
The Explorers (6-4) benefited from 20 points, seven rebounds and five assists from Jerrell Williams in the loss.
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