After playing a tight first 20 minutes, the Aztecs (10-0) outscored their crosstown rivals 43-21 in the second half.
Kawhi Leonard chipped in with 13 points and 13 rebounds for San Diego State, which is off to the best start in school history.
The Toreros (1-8) were led by Ken Rancifer and Trevor Fuller, who each scored 12 points in the setback.
Copyright 2010 United Press International, Inc. (UPI).