Purdue took the lead for good with a 16-4 run early in the first half, during which Johnson hit two jumpers and Moore connected on a pair of 3-pointers for the Boilermakers (9-1) on the way to a 20-8 lead.
Terone Johnson's basket with 1:22 remaining in the first half gave Purdue a 41-21 lead at the break and the Boilermakers cruised from there.
Jerron Granberry donated 14 points for the Ospreys (4-5) and Brad Haugabrook chipped in 12 with four assists.
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