D.J. Byrd and John Hart each connected on four 3-pointers and ended with 12 points in the season-opening victory for Purdue.
JaJuan Johnson chipped in with 10 points and 12 rebounds as the Boilermakers won without forward Robbie Hummel, who will miss the entire season after suffering a torn knee ligament in October.
Howard (1-1) got 10 points and nine rebounds from Alphonso Leary.
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