Blake posted only his second service break of the match in the ninth game of the third set but made it stand for a 3-6, 6-4, 6-4 victory over seventh-seeded Thomaz Bellucci. Bellucci took the first set behind a pair of breaks but Blake saved all four of the break points he faced the rest of the way.
Sixth-seeded Feliciano Lopez and No. 8-seeded Tommy Robredo also fell Tuesday.
Robredo was dumped by qualifier Ivan Dodig 6-3, 6-2 in just 64 minutes. Dodig won 60 percent of the points in the match.
Florian Mayer needed just 56 minutes to oust Lopez, winning 6-2, 6-2 after losing only 12 points over eight service games.
Robin Haase took a 7-6 (7-4), 3-6, 6-4 decision from Filip Prpic while Arnaud Clement beat Olivier Rochus 6-0, 6-4 and Benjamin Becker routed Thomas Schoorel 6-3, 6-0 in other matches.
Also, Taylor Dent advanced when Michal Pryzsiezny suffered an ankle injury with Dent up 6-2. That set up a match for Dent with top-seeded and world No. 2 Roger Federer.
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