Querrey, the No. 2 seed, needed 2 1/2 hours to defeat the Scot, overcoming an 0-4 career mark against Murray -- a record that included a straight-set defeat at Wimbledon last month.
With the win, the American player became the first back-to-back champion in Los Angeles since Andre Agassi accomplished the feat in 2001-02.
Querrey earned his sixth career title and improved to 4-1 in title matches.
Murray, meanwhile, came up short in a final for the second time this year. He also fell in the Australian Open final to Roger Federer.
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