The hip-hop artist is currently serving a 1-year prison sentence in New York for weapons charges in a separate 2007 case and couldn't attend the Arizona hearing in person.
Lil' Wayne is expected to appear in Yuma County Superior Court to confirm the plea deal for the Arizona charges after he is released from prison, CNN said.
The recording artist could receive 36 months probation in exchange for his guilty plea, the news network said on its Web site.
He was arrested in 2008 after the drug ecstasy was allegedly found in his backpack on his tour bus.
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