After being shut out over nine innings by Reds starter Mike Leake and four relievers, pinch-hitter Cory Sullivan and Michael Bourn each drew one-out walks from Micah Owings (3-1) in the 10th.
After Jeff Keppinger fouled out, Berkman lined a double into the right field corner, plating two runs and enabling the Houston to salvage one game of weekend series at Great American Park.
Starter Felipe Paulino was tough for the Astros, shutting the Reds out on four hits over eight innings despite allowing four walks. But it was Brandon Lyon (4-1) who picked up the win by hurling a scoreless ninth and Matt Lindstrom notched his 11th save.
Leake scattered seven hits over six innings for Cincinnati, walking three and fanning three in the no-decision.
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