Vonn covered the course at Cortina D'Ampezzo, Italy, in 1 minute, 21.74 seconds, easily ahead of runner-up Swiss Fabienne Suter (1:22.41) and third-place Swede Anja Paerson (1:22.48).
The victory came on the heels of a super-G win 12 days ago and gave Vonn four podium appearances in four super-Gs this season. She easily leads the season-long super-G standings by 170 points over Suter.
Friday's results also boosted Vonn, the two-time defending World Cup champion, into the overall standings lead by 56 points over German Maria Riesch.
"I'm really happy," Vonn said. "It couldn't be going any better for me right now in the speed disciplines. It's nice to have the confidence back and have a more positive race after the last week of technical races."
The women skiers head to St. Moritz, Switzerland, next week for the final set of races before the 2010 Winter Olympics open Feb. 12 in Canada.
Copyright 2010 by United Press International.