Manning ran his career TD pass total to 345 -- leaving him second in NFL history behind Brett Favre, who has 47, and Dan Marino who finished with 420. Manning -- who was intercepted once in the game -- has thrown for more than 300 yards in all five of the Colts (5-0) games so far this season.
Austin Collie caught eight passes for 97 yards and two touchdowns and Joseph Addai scored a rushing TD for Indianapolis.
Titans quarterback Kerry Collins was 19-of-32 passing for 164 yards and one interception. Vince Young took over for Tennessee (0-5) with 7:26 left to play.
After starting last season 10-0 and winning the AFC South title, the Titans are off to their worst start since they opened at 0-5 in 2006.
Copyright 2009 by United Press International.