Busch, who won at Dover a year ago, had the dominant car for the first half of the 200-lap race but Bowyer came on strong shortly after the midway point.
Bowyer, the 2008 Nationwide champion, got his second win in his ninth start this season and his eighth career victory.
Mike Bliss finished second while Brad Keselowski came in third. Keselowski bumped Denny Hamlin from behind, sending Hamlin into the inside wall after he was running in the fourth spot.
At the end of the race, which was threatened by incoming rain, Hamlin waited for Keselowski on the pit road, but both teams prevented any post-race altercations that might have occurred.
Busch wound up with a fourth-place finish. He padded his series lead to 211 points over Carl Edwards, who finished fifth Saturday.
Copyright 2009 by United Press International.
Post new comment