Roger Federer and Rafael Nadal, the event's top two seeds, both advanced and Andy Murray survived as well.
The fifth-seeded Roddick, however, lost a 13-11 tiebreak in the opening set and then dropped the second in a 7-3 tiebreaker. That put Querrey in the third round against Lleyton Hewitt, who defeated Benjamin Becker 6-3, 6-3.
Federer opened his tournament with a 6-3, 7-5 victory over Jose Acasuso. That set up a third-round meeting with David Ferrer, who had won his second-round match Tuesday.
Nadal, who has slipped to third in the world behind Murray but is still seeded above Murray in this tournament, survived against Andreas Seppi 7-6 (7-4), 7-6 (7-3). Next up for Nadal will be Paul-Henri Mathieu, who defeated Ivo Karlovic 7-6 (11-9), 6-4.
Murray earned his third-round berth by downing Nicolas Almagro 7-6 (7-3), 6-2.
Copyright 2009 by United Press International.