Glen Perkins (6-6) got the win after working seven innings and giving up three runs on six hits.
Joe Nathan pitched a 1-2-3 ninth to earn his 27th save.
Denard Span had a triple for the Twins.
John Danks (8-7) took the loss after allowing four runs on six hits in seven innings.
Paul Konerko had a two-run homer and Gordon Beckham had a solo shot for Chicago.
Copyright 2009 by United Press International.