The Padres lost their fifth straight.
San Francisco held onto its 2-0 advantage until the sixth, when the Giants blew the game open on solo homers by Travis Ishikawa and Juan Uribe, along with a two-run double by Pablo Sandoval.
Tim Lincecum (10-2) took a shutout into the seventh, but wound up surrendering two runs on three hits in 6 2/3 innings.
The loss went to Josh Geer (1-4), who was touched for six runs on seven hits in 4 2/3.
Lincecum struck out eight to run his National League-leading total to 149. He is in a position to challenge for his second consecutive Cy Young Award.
Copyright 2009 by United Press International.
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