Jermaine Dye added a two-run homer, Brian Anderson had two RBI, and Paul Konerko was 3-for-4 with an RBI and two runs scored for the White Sox.
Mark Buehrle (3-0) worked six innings and gave up two runs on six hits.
Octavio Dotel, Matt Thornton and Scott Linebrink combined on three innings of one-hit relief.
Marco Scutaro and Jose Bautista each drove in a run for Toronto.
Brian Burres (0-1), called up Friday from Triple-A Las Vegas, took the loss after allowing six runs on seven hits in 4 1/3 innings.
Copyright 2009 by United Press International.